Nolensville running back Colton Dooley scored three first-half touchdowns, leading the Knights to a 42-7 playoff win over at Macon County.
Wesley Jones also had a first-half touchdown reception for the Knights, and picked off a pass, too.
NHS (7-4) has won three straight. The Knights travel to 10-1 Maplewood for a second-round game next Friday.
Quarterback Ryder Galardi added a second-half score, as did running back Ryan Pistulka.
Nolensville, in its second year of football, also won a first-round playoff game last season.