Centennial came in riding high off a close win over Ravenwood last week, while Hendersonville was still reeling from a pasting by Blackman.
Things went in opposite direction on Friday.
Centennial gave up 28 first-quarter points and never caught up, as the Commandos knocked off the Cougars, 56-21, in Hendersonville.
Centennial trailed 35-21 at half.
The Cougars will play their third-straight road contest next week, this one coming at Independence.