| Home Team | Away Team | Time of kick-off (CST) | TV Channel | Online Stream | (Result) |
| Saturday, October 22 | |||||
| South Carolina Gamecocks | UMass Minutemen | 11:00 AM | SEC Network | WatchESPN | |
| (1) Alabama Crimson Tide | (6) Texas A&M | 2:30 PM | CBS | CBSsports.com | |
| Missouri Tigers | MTSU Blue Raiders | 3:00 PM | SEC Network | WatchESPN | |
| (17) Arkansas Razorbacks | (21) Auburn Tigers | 5:00 PM | ESPN | WatchESPN | |
| WKU Hilltoppers | Old Dominion Monarchs | 6:00 PM | N/A | ASN | |
| Kentucky Wildcats | Mississippi State Bulldogs | 6:30 PM | SEC Network | WatchESPN | |
| Vanderbilt Commodores | TSU Tigers | 6:30 PM | ESPNU | WatchESPN | |
| (25) LSU Tigers | (23) Ole Miss Rebels | 8:00 PM | ESPN | WatchESPN | |
| Bye week: Florida Gators, Georgia Bulldogs, Tennessee Volunteers | |||||
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